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Creative Biolabs
City:
New York
Industry:
Health Medical
Country/Region:
United States United States
Business Type:
Professional
 

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Anti-STEAP1-Mc-VC-PABC-MMAE ADC

Anti-STEAP1-Mc-VC-PABC-MMAE ADC

Product Name Anti-STEAP1-Mc-VC-PABC-MMAE ADC
Company Creative Biolabs
Short description Anti-STEAP1-Mc-VC-PABC-MMAE ADC
Detail https://www.creative-biolabs.com/adc/target-steap1-92.htm This ADC product is comprised of an anti-STEAP1 monoclonal antibody conjugated via a Mc-VC-PABC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death. Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood. Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Title Anti-STEAP1-Mc-VC-PABC-MMAE ADC
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Anti-STEAP1-Mc-VC-PABC-MMAE ADCAnti-STEAP1-Mc-VC-PABC-MMAE ADC
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