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Creative Biolabs
City:
New York
Industry:
Pharmaceuticals
Country/Region:
United States United States
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Professional
 

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Fab PEGylation

Fab PEGylation

Product Name Fab PEGylation
Company Creative Biolabs
Short description Fab PEGylation
Detail Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology.More information, please visit the website: http://www.creative-biolabs.com/fab-pEGylation.html
Title Health&Medical-Biological Products
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